Enter your details:
Thank you for subscribing.
Subscribe to our newsletter!

Yosnengsih1, Bambang Purwanto1, Angelia Indra Devi1, Siti Badriyah Zahrotul Ilmi1, Aldi Karimullah1, Fajar Syamsudin2, Novadri Ayubi3, Cyuzuzo Callixte4, Pudia M. Indika5, Lilik Herawati1

1Department of Physiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
2Faculty of Sport Science, Universitas Negeri Semarang, Semarang, Indonesia
3Faculty of Sport Science, Universitas Negeri Surabaya, Surabaya, Indonesia
4Departement of Biomedical Laboratory Science, Faculty of Health Science, Kibogora Polytechnic University, Rwanda
5Faculty of Sport Science, Universitas Negeri Padang, Padang, Indonesia

Single Bout High Intensity Interval Exercise (HIIE) Prevents Adiponectin Reduction in Sedentary Overweight Women

Sport Mont 2023, 21(1), 3-8 | DOI: 10.26773/smj.230201


This study aimed to analyze the effect of a single bout of high-intensity intermittent exercise (HIIE) on serum adiponectin levels in sedentary overweight young adult women. A total of 22 overweight adult obesity women with a BMI of 23-24.9 m2/kg were enrolled in this study. Subjects were divided into 2 groups, control and HIIE. The exercise was static cycling for a total of 25 minutes (3 minutes warming up, 20 minutes HIIE, and 2 minutes cooling down). The HIIE was held 10 sets intermittently with the ratio 1:1, 1 minute cycling in 80-90% HRmax, 1 minute active resting with 40 rpm cycling. The data in this study were taken before and 1 hour after the HIIE. The adiponectin level was measured using a human ELISA kit. The adiponectin level in the control group reduced significantly (p<0.05), however, the HIIE group reduced insignificantly. A single bout of HIIE in sedentary overweight young adult women can maintain the adiponectin level. Therefore, it may have a positive contribution to women’s health. However, further research needs to be conducted to uncover the underlying mechanism.


HIIE, adiponectin, overweight, sedentary, women, healthy lifestyle

View full article
(PDF – 237KB)


Cipryan, L., Dostal, T., Plews, D.J., Hofmann, P., & Laursen, P.B. (2021). Adiponectin/leptin ratio increases after a 12-week very low-carbohydrate, high-fat diet, and exercise training in healthy individuals: A non-randomized, parallel design study. Nutrition Research, 87, 22-30. https://doi.org/https://doi.org/10.1016/j.nutres.2020.12.012

Cho, J.K., Kim, S.U., Hong, H.R., Yoon, J.H., & Kang, H.S. (2015). Exercise training improves whole body insulin resistance via adiponectin receptor 1. International Journal of Sports Medicine, 36 (13), e24-e30. https://doi.org/10.1055/s-0035-1559715.

de Lemos, T.E., Oliveira, J., Páscoa-Pinheiro, J., & Reis, F. (2012). Regular physical exercise as a strategy to improve antioxidant and anti-inflammatory status: benefits in type 2 diabetes mellitus. Oxidative Medicine and Cellular Longevity, 741545, 1-15. https://doi.org/10.1155/2012/741545.

de Souza, D.C., Matos, V.A., Dos Santos, V.O., Medeiros, I.F., Marinho, C.S., Nascimento, P.R., ... & Fayh, A.P. (2018). Effects of high-intensity interval and moderate-intensity continuous exercise on inflammatory, leptin, IgA, and lipid peroxidation responses in obese males. Frontiers in Physiology, 9, 567. https://doi.org/10.3389/fphys.2018.00567.

Fang, H., & Judd, R.L. (2018). Adiponectin Regulation and Function. Correspondence Auburn University, College Of Veterinary Medicine, Boshell Diabetes And Metabolic Diseases Research Program. Comprehensive Physiology, 1031-1063. https://doi.org/10.1002/cphy.c170046.

Gilbertson, N.M., Eichner, N.Z., Heiston, E.M., Gaitán, J.M., Francois, M.E., Mehaffey, J.H., ... & Malin, S.K. (2019). A low-calorie diet with or without interval exercise training improves adiposopathy in obese women. Applied Physiology, Nutrition, and Metabolism, 44(10), 1057-1064. https://doi.org/10.1139/apnm-2018-0717.

García-Hermoso, A., Ceballos-Ceballos, R.J.M., Poblete-Aro, C.E., Hackney, A.C., Mota, J., & Ramírez-Vélez, R. (2017). Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials. International Journal of Obesity, 41(4), 475-482. https://doi.org/10.1038/ijo.2016.230.

Heydari, M., Freund, J., & Boutcher, S.H. (2012). The effect of high-intensity intermittent exercise on body composition of overweight young males. Journal of Obesity, 480467, 1-8. https://doi.org/10.1155/2012/480467.

Hojbjerre, L., Rosenzweig, M., Dela, F., Bruun, J.M., & Stallknecht, B. (2007). Acute exercise increases adipose tissue interstitial adiponectin concentration in healthy overweight and lean subjects. European Journal of Endocrinology, 157(5), 613-624. https://doi.org/10.1530/EJE-07-0213.

Kao, H.H., Hsu, H.S., Wu, T.H., Chiang, H.F., Huang, H.Y., Wang, H.J., ... & Lin, W.Y. (2021). Effects of a single bout of short-duration high-intensity and long-duration low-intensity exercise on insulin resistance and adiponectin/leptin ratio. Obesity Research & Clinical Practice, 15(1), 58-63. https://doi.org/10.1016/j.orcp.2020.09.007.

Kelly, K.R., Navaneethan, S.D., Solomon, T.P., Haus, J.M., Cook, M., Barkoukis, H., & Kirwan, J.P. (2014). Lifestyle-induced decrease in fat mass improves adiponectin secretion in obese adults. Medicine and Science in Sports and Exercise, 46(5), 920. https://doi.org/10.1249/MSS.0000000000000200

Kim, J., Lee, I., & Lim, S. (2017). Overweight or obesity in children aged 0 to 6 and the risk of adult metabolic syndrome: A systematic review and meta‐analysis. Journal of Clinical Nursing, 26(23-24), 3869-3880. https://doi.org/10.1111/jocn.13802.

de Farias Lelis, D., de Freitas, D.F., Machado, A.S., Crespo, T.S., & Santos, S.H.S. (2019). Angiotensin (1-7), adipokines and inflammation. Metabolism, 95, 36-45. https://doi.org/10.1016/j.metabol.2019.03.006.

Mansouri, M., Keshtkar, A., Hasani-Ranjbar, S., Far, E.S., Tabatabaei-Malazy, O., Omidfar, K., & Larijani, B. (2011). The impact of one session resistance exercise on plasma adiponectin and RBP4 concentration in trained and untrained healthy young men. Endocrine Journal, 58(10), 861–868. https://doi.org/10.1507/endocrj.EJ11-0046.

Martins, L.C.G., Lopes, M.V.D.O., Diniz, C.M., & Guedes, N.G. (2021). The factors related to a sedentary lifestyle: A meta‐analysis review. Journal of Advanced Nursing, 77(3), 1188-1205. https://doi.org/10.1111/jan.14669.

Nieste, I., Franssen, W.M., Spaas, J., Bruckers, L., Savelberg, H.H., & Eijnde, B. O. (2021). Lifestyle interventions to reduce sedentary behaviour in clinical populations: a systematic review and meta-analysis of different strategies and effects on cardiometabolic health. Preventive Medicine, 148, 106593. https://doi.org/10.1016/j.ypmed.2021.106593.

Okauchi, Y., Nishizawa, H., Funahashi, T., Ogawa, T., Noguchi, M., Ryo, M., ... & Matsuzawa, Y. (2007). Reduction of visceral fat is associated with decrease in the number of metabolic risk factors in Japanese men. Diabetes Care, 30(9), 2392-2394. https://doi.org/10.2337/dc07-0218.

Otu, L.I., & Otu, A. (2021). Adiponectin and the Control of Metabolic Dysfunction: Is Exercise the Magic Bullet?. Frontiers in Physiology, 440. https://doi.org/10.3389/fphys.2021.651732.

Pop, D.A.N.A., Bodisz, G., Petrovai, D., Borz, B., Zdrenghea, V., & Zdrenghea, D. (2010). The effect of very short duration acute physical exercise upon adiponectin and leptin in overweight subjects. Romanian Journal of Internal Medicine, 48(1), 39-45.

Rachmi, C.N., Li, M., & Baur, L.A. (2017). Overweight and obesity in Indonesia: prevalence and risk factors - a literature review. Public Health, 147, 20-29. https://doi.org/10.1016/j. puhe.2017.02.002.

Racil, G., Coquart, J.B., Elmontassar, W., Haddad, M., Goebel, R., Chaouachi, A., ... & Chamari, K. (2016). Greater effects of high-compared with moderate-intensity interval training on cardio-metabolic variables, blood leptin concentration and ratings of perceived exertion in obese adolescent females. Biology of Sport, 33(2), 145-152. https://doi.org/10.5604/20831862.1198633.

Rossi, F.E., Diniz, T.A., Neves, L.M., Fortaleza, A.C.S., Gerosa-Neto, J., Inoue, D.S., ... & Freitas, I.F. (2017). The beneficial effects of aerobic and concurrent training on metabolic profile and body composition after detraining: a 1-year follow-up in postmenopausal women. European Journal of Clinical Nutrition, 71(5), 638-645. https://doi.org/10.1038/ejcn. 2016.263 PMID: 28120855.

Saunders, T.J., Palombella, A., McGuire, K.A., Janiszewski, P.M., Després, J.P., & Ross, R. (2012). Acute exercise increases adiponectin levels in abdominally obese men. Journal of Nutrition and Metabolism, 148729. https://doi.org/10.1155/2012/148729

Simpson, K.A., & Singh, M.A.F. (2008). Effects of exercise on adiponectin: a systematic review. Obesity, 16(2), 241-256. https://doi.org/10.1038/oby.2007.53

Sirico, F., Bianco, A., D'Alicandro, G., Castaldo, C., Montagnani, S., Spera, R., ... & Nurzynska, D. (2018). Effects of physical exercise on adiponectin, leptin, and inflammatory markers in childhood obesity: systematic review and meta-analysis. Childhood Obesity, 14(4), 207-217. https://doi.org/10.1089/chi.2017.0269

Varady, K.A., Bhutani, S., Church, E.C., & Phillips, S.A. (2010). Adipokine Responses To Acute Resistance Exercise In Trained And Untrained Men. Medicine & Science in Sports & Exercise, 42(3), 456–462. https://doi.org/10.1249/MSS.0b013e3181ba6dd3.

Vardar, S.A., Karaca, A., Güldiken, S., Palabıyık, O., Süt, N., & Demir, A.M. (2018). High-intensity interval training acutely alters plasma adipokine levels in young overweight/obese women. Archives of Physiology and Biochemistry, 124 (2), 149-155. https://doi.org/10.1080/13813455.2017.1369998

Versini, M., Jeandel, P.Y., Rosenthal, E., & Shoenfeld, Y. (2014). Obesity in autoimmune diseases: not a passive bystander. Autoimmunity Reviews, 13(9), 981-1000. http://dx.doi.org/10.1016/j.autrev.2014.07.001

Zaidi, H., Byrkjeland, R., Njerve, I.U., Åkra, S., Solheim, S., Arnesen, H., ... & Opstad, T.B. (2021). Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease. Adipocyte, 10 (1), 612-620. https://doi.org/10.1080/21623945.2021.1996699.